GrippeEspagneV1, Main, Exploration, bibRecord, 000172

Viral coinfection in childhood respiratory tract infections.

Identifieur interne : 000172 ( Main/Exploration ); précédent : 000171; suivant : 000173

Viral coinfection in childhood respiratory tract infections.

Auteurs : A. Martínez-Roig [Espagne] ; M. Salvad [Espagne] ; M A Caballero-Rabasco [Espagne] ; A. Sánchez-Buenavida [Espagne] ; N. L Pez-Segura [Espagne] ; M. Bonet-Alcaina [Espagne]

Source :

Archivos de bronconeumologia [ 1579-2129 ] ; 2015.

RBID : pubmed:24666712

Descripteurs français

KwdFr :
- Adolescent (MeSH), Anti-infectieux (usage thérapeutique), Association thérapeutique (MeSH), Co-infection (épidémiologie), Durée du séjour (statistiques et données numériques), Enfant (MeSH), Enfant d'âge préscolaire (MeSH), Espagne (épidémiologie), Femelle (MeSH), Humains (MeSH), Infection croisée (microbiologie), Infection croisée (virologie), Infection croisée (épidémiologie), Infections bactériennes (épidémiologie), Infections de l'appareil respiratoire (microbiologie), Infections de l'appareil respiratoire (virologie), Infections de l'appareil respiratoire (épidémiologie), Maladies virales (épidémiologie), Mâle (MeSH), Nourrisson (MeSH), Nouveau-né (MeSH), Oxygénothérapie (MeSH), Partie nasale du pharynx (virologie), Patients hospitalisés (MeSH), Réaction de polymérisation en chaîne (méthodes), Unités de soins intensifs pédiatriques (statistiques et données numériques), Ventilation artificielle (MeSH), Virus (isolement et purification).
MESH :
- isolement et purification : Virus.
- microbiologie : Infection croisée, Infections de l'appareil respiratoire.
- méthodes : Réaction de polymérisation en chaîne.
- statistiques et données numériques : Durée du séjour, Unités de soins intensifs pédiatriques.
- usage thérapeutique : Anti-infectieux.
- virologie : Infection croisée, Infections de l'appareil respiratoire, Partie nasale du pharynx.
- épidémiologie : Co-infection, Espagne, Infection croisée, Infections bactériennes, Infections de l'appareil respiratoire, Maladies virales.
- Adolescent, Association thérapeutique, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Mâle, Nourrisson, Nouveau-né, Oxygénothérapie, Patients hospitalisés, Ventilation artificielle.

English descriptors

KwdEn :
- Adolescent (MeSH), Anti-Infective Agents (therapeutic use), Bacterial Infections (epidemiology), Child (MeSH), Child, Preschool (MeSH), Coinfection (epidemiology), Combined Modality Therapy (MeSH), Cross Infection (epidemiology), Cross Infection (microbiology), Cross Infection (virology), Female (MeSH), Humans (MeSH), Infant (MeSH), Infant, Newborn (MeSH), Inpatients (MeSH), Intensive Care Units, Pediatric (statistics & numerical data), Length of Stay (statistics & numerical data), Male (MeSH), Nasopharynx (virology), Oxygen Inhalation Therapy (MeSH), Polymerase Chain Reaction (methods), Respiration, Artificial (MeSH), Respiratory Tract Infections (epidemiology), Respiratory Tract Infections (microbiology), Respiratory Tract Infections (virology), Spain (epidemiology), Virus Diseases (epidemiology), Viruses (isolation & purification).
MESH :
- chemical , therapeutic use : Anti-Infective Agents.
- epidemiology : Bacterial Infections, Coinfection, Cross Infection, Respiratory Tract Infections, Spain, Virus Diseases.
- isolation & purification : Viruses.
- methods : Polymerase Chain Reaction.
- microbiology : Cross Infection, Respiratory Tract Infections.
- statistics & numerical data : Intensive Care Units, Pediatric, Length of Stay.
- virology : Cross Infection, Nasopharynx, Respiratory Tract Infections.
- Adolescent, Child, Child, Preschool, Combined Modality Therapy, Female, Humans, Infant, Infant, Newborn, Inpatients, Male, Oxygen Inhalation Therapy, Respiration, Artificial.

Abstract

INTRODUCTION

The introduction of molecular techniques has enabled better understanding of the etiology of respiratory tract infections in children. The objective of the study was to analyze viral coinfection and its relationship to clinical severity.

METHODS

Hospitalized pediatric patients with a clinical diagnosis of respiratory infection were studied during the period between 2009-2010. Clinical and epidemiological data, duration of hospitalization, need for oxygen therapy, bacterial coinfection and need for mechanical ventilation were collected. Etiology was studied by multiplex PCR and low-density microarrays for 19 viruses.

RESULTS

A total of 385 patients were positive, 44.94% under 12 months. The most frequently detected viruses were RSV-B: 139, rhinovirus: 114, RSV-A: 111, influenza A H1N1-2009: 93 and bocavirus: 77. Coinfection was detected in 61.81%, 36.36% with 2 viruses, 16.10% and 9.35% with 3 to 4 or more. Coinfection was higher in 2009 with 69.79 vs. 53.88% in 2010. Rhinovirus/RSV-B on 10 times and RSV-A/RSV-B on 5 times were the most detected coinfections. Hospitalization decreased with greater number of viruses (P<0,001). Oxygen therapy was required by 26.75% (one virus was detected in 55.34% of cases). A larger number of viruses resulted in less need for oxygen (P<0,001). Ten cases required mechanical ventilation, 4 patients with bacterial coinfection and 5 with viral coinfection (P=0,69).

CONCLUSIONS

An inverse relationship was found between the number of viruses detected in nasopharyngeal aspirate, the need for oxygen therapy and hospitalization days. More epidemiological studies and improved quantitative detection techniques are needed to define the role of viral coinfections in respiratory disease and its correlation with the clinical severity.

DOI: 10.1016/j.arbres.2014.01.018
PubMed: 24666712
PubMed Central: PMC7105245

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 00212
to stream Main, to step Curation: 000212

Le document en format XML

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<term>Anti-Infective Agents (therapeutic use)</term>
<term>Bacterial Infections (epidemiology)</term>
<term>Child (MeSH)</term>
<term>Child, Preschool (MeSH)</term>
<term>Coinfection (epidemiology)</term>
<term>Combined Modality Therapy (MeSH)</term>
<term>Cross Infection (epidemiology)</term>
<term>Cross Infection (microbiology)</term>
<term>Cross Infection (virology)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Infant (MeSH)</term>
<term>Infant, Newborn (MeSH)</term>
<term>Inpatients (MeSH)</term>
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<term>Length of Stay (statistics & numerical data)</term>
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<term>Nasopharynx (virology)</term>
<term>Oxygen Inhalation Therapy (MeSH)</term>
<term>Polymerase Chain Reaction (methods)</term>
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<term>Respiratory Tract Infections (microbiology)</term>
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<term>Association thérapeutique (MeSH)</term>
<term>Co-infection (épidémiologie)</term>
<term>Durée du séjour (statistiques et données numériques)</term>
<term>Enfant (MeSH)</term>
<term>Enfant d'âge préscolaire (MeSH)</term>
<term>Espagne (épidémiologie)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Infection croisée (microbiologie)</term>
<term>Infection croisée (virologie)</term>
<term>Infection croisée (épidémiologie)</term>
<term>Infections bactériennes (épidémiologie)</term>
<term>Infections de l'appareil respiratoire (microbiologie)</term>
<term>Infections de l'appareil respiratoire (virologie)</term>
<term>Infections de l'appareil respiratoire (épidémiologie)</term>
<term>Maladies virales (épidémiologie)</term>
<term>Mâle (MeSH)</term>
<term>Nourrisson (MeSH)</term>
<term>Nouveau-né (MeSH)</term>
<term>Oxygénothérapie (MeSH)</term>
<term>Partie nasale du pharynx (virologie)</term>
<term>Patients hospitalisés (MeSH)</term>
<term>Réaction de polymérisation en chaîne (méthodes)</term>
<term>Unités de soins intensifs pédiatriques (statistiques et données numériques)</term>
<term>Ventilation artificielle (MeSH)</term>
<term>Virus (isolement et purification)</term>
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<term>Cross Infection</term>
<term>Respiratory Tract Infections</term>
<term>Spain</term>
<term>Virus Diseases</term>
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<term>Infections de l'appareil respiratoire</term>
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<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Cross Infection</term>
<term>Respiratory Tract Infections</term>
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<keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Réaction de polymérisation en chaîne</term>
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<term>Unités de soins intensifs pédiatriques</term>
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<term>Infections de l'appareil respiratoire</term>
<term>Partie nasale du pharynx</term>
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<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Cross Infection</term>
<term>Nasopharynx</term>
<term>Respiratory Tract Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Co-infection</term>
<term>Espagne</term>
<term>Infection croisée</term>
<term>Infections bactériennes</term>
<term>Infections de l'appareil respiratoire</term>
<term>Maladies virales</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Combined Modality Therapy</term>
<term>Female</term>
<term>Humans</term>
<term>Infant</term>
<term>Infant, Newborn</term>
<term>Inpatients</term>
<term>Male</term>
<term>Oxygen Inhalation Therapy</term>
<term>Respiration, Artificial</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Association thérapeutique</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>Nouveau-né</term>
<term>Oxygénothérapie</term>
<term>Patients hospitalisés</term>
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<front><div type="abstract" xml:lang="en"><p><b>INTRODUCTION</b>
</p>
<p>The introduction of molecular techniques has enabled better understanding of the etiology of respiratory tract infections in children. The objective of the study was to analyze viral coinfection and its relationship to clinical severity.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>Hospitalized pediatric patients with a clinical diagnosis of respiratory infection were studied during the period between 2009-2010. Clinical and epidemiological data, duration of hospitalization, need for oxygen therapy, bacterial coinfection and need for mechanical ventilation were collected. Etiology was studied by multiplex PCR and low-density microarrays for 19 viruses.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>A total of 385 patients were positive, 44.94% under 12 months. The most frequently detected viruses were RSV-B: 139, rhinovirus: 114, RSV-A: 111, influenza A H1N1-2009: 93 and bocavirus: 77. Coinfection was detected in 61.81%, 36.36% with 2 viruses, 16.10% and 9.35% with 3 to 4 or more. Coinfection was higher in 2009 with 69.79 vs. 53.88% in 2010. Rhinovirus/RSV-B on 10 times and RSV-A/RSV-B on 5 times were the most detected coinfections. Hospitalization decreased with greater number of viruses (P<0,001). Oxygen therapy was required by 26.75% (one virus was detected in 55.34% of cases). A larger number of viruses resulted in less need for oxygen (P<0,001). Ten cases required mechanical ventilation, 4 patients with bacterial coinfection and 5 with viral coinfection (P=0,69).</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>An inverse relationship was found between the number of viruses detected in nasopharyngeal aspirate, the need for oxygen therapy and hospitalization days. More epidemiological studies and improved quantitative detection techniques are needed to define the role of viral coinfections in respiratory disease and its correlation with the clinical severity.</p>
</div>
</front>
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<DateCompleted><Year>2015</Year>
<Month>09</Month>
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<Title>Archivos de bronconeumologia</Title>
<ISOAbbreviation>Arch. Bronconeumol.</ISOAbbreviation>
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<ArticleTitle>Viral coinfection in childhood respiratory tract infections.</ArticleTitle>
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<Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">The introduction of molecular techniques has enabled better understanding of the etiology of respiratory tract infections in children. The objective of the study was to analyze viral coinfection and its relationship to clinical severity.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Hospitalized pediatric patients with a clinical diagnosis of respiratory infection were studied during the period between 2009-2010. Clinical and epidemiological data, duration of hospitalization, need for oxygen therapy, bacterial coinfection and need for mechanical ventilation were collected. Etiology was studied by multiplex PCR and low-density microarrays for 19 viruses.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">A total of 385 patients were positive, 44.94% under 12 months. The most frequently detected viruses were RSV-B: 139, rhinovirus: 114, RSV-A: 111, influenza A H1N1-2009: 93 and bocavirus: 77. Coinfection was detected in 61.81%, 36.36% with 2 viruses, 16.10% and 9.35% with 3 to 4 or more. Coinfection was higher in 2009 with 69.79 vs. 53.88% in 2010. Rhinovirus/RSV-B on 10 times and RSV-A/RSV-B on 5 times were the most detected coinfections. Hospitalization decreased with greater number of viruses (P<0,001). Oxygen therapy was required by 26.75% (one virus was detected in 55.34% of cases). A larger number of viruses resulted in less need for oxygen (P<0,001). Ten cases required mechanical ventilation, 4 patients with bacterial coinfection and 5 with viral coinfection (P=0,69).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">An inverse relationship was found between the number of viruses detected in nasopharyngeal aspirate, the need for oxygen therapy and hospitalization days. More epidemiological studies and improved quantitative detection techniques are needed to define the role of viral coinfections in respiratory disease and its correlation with the clinical severity.</AbstractText>
<CopyrightInformation>Copyright © 2013 SEPAR. Published by Elsevier Espana. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Martínez-Roig</LastName>
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Viral coinfection in childhood respiratory tract infections.

Viral coinfection in childhood respiratory tract infections.

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